NAD+ Defender – Anti-Inflammatory (60 Capsules)

£59.95 or subscribe and save 5%

  • 60 capsules per bottle
  • Liposomal CaAKG – 110 mg
  • Liposomal Berberine – 60 mg
  • Liposomal Hyaluronic Acid (HLA)- 60 mg
  • cGMP Certified – This product is made in an FDA-approved facility
  • No artificial colours, flavours or preservatives. Non-GMO
  • Suitable for vegans

As you age, inflammation becomes the key consumer of NAD+ and levels drop. Decreasing systemic inflammation minimises NAD+ consumption, so it’s available for other purposes.

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Description

About Defender

Defender is a unique combination of supplements formulated to reduce systemic inflammation.  Decreasing systemic inflammation will minimize NAD+ consumption so that it’s available for other purposes.

We combine Lipo Berberine, Lipo CaAKG, and Lipo HLA, which work together to help prevent cellular senescence and slow the rate of age-related DNA methylation, which can help to prevent some of the many “diseases of old age”.

Defender can also elevate levels of NAD+ by increasing an important enzyme responsible for the conversion of nicotinamide to NAD+, called NAMPT.  Defender is also formulated to promote new cartilage and bone, thereby reducing joint inflammation and pain.

About Liposomal Delivery

Our Lipo products are part of a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.

Our process encapsulates and delivers our products intracellularly in their complete form where they can be absorbed and utilized rather than being destroyed in the stomach.

Lipo Berberine

Berberine is an alkaloid found in a variety of plants. It is similar to metformin in that it can help to regulate glucose and lipid metabolism.

Berberine Found to Increase NAD+ Levels, Lower Inflammation

In a study examining the effects of Berberine on NAD+ levels, it was found that Berberine increases an important enzyme responsible for the conversion of nicotinamide to NAD+, called NAMPT.

“Berberine increases NAD+/NADH ratio through induction of NAMPT expression in C2C12 cells” (1)

As we age, we accumulate senescent cells that secrete toxins which are inflammatory.  Berberine is one of the most promising interventions to slow the accumulation of senescent cells and the inflammation they secrete by inducing autophagy, the body’s way of clearing out dead and damaged cells to make way for new ones.

“Mechanistic studies exhibit that berberine induces autophagic death in ALL cells by inactivating AKT/mTORC1 signaling” (2)

Berberine’s benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome. It has also been shown to increase NAD+ levels through its activation of the AMPK enzyme.

“The beneficial effects of BBR are attributable to its effect as an AMPK activator”  (3)

“Berberine has been shown to enhance AMPK activation (one of the few chemicals that does), enhance autophagy and mitigate apoptosis (cell death) induced by high glucose levels” (7)

“AMPK regulates an array of biological activities that normalize lipid, glucose, and energy imbalances” (7)

Research also indicates there is an important synergy between two ingredients, berberine and CaAKG.  AMPK is upregulated by berberine and AMPK upregulates isocitrate dehydrogenase in the Krebs cycle, which produces alpha-ketoglutarate (AKG).

LIPO Berberine™ offers advanced support for:

▸  Metabolic function and clearing senescent cells

▸  Weight Management

▸  AMPK activation

▸  Blood sugar and insulin metabolism

▸  Microbiome balance

Lipo CaAKG

Calcium-alpha-ketoglutarate (CaAKG for short) is a special form of mineral calcium used to restore calcium concentration levels in the blood back to normal.

CaAKG Slows Effects of Aging and Reduces Inflammation

CaAKG works by slowing the rate of age-related DNA methylation and reducing the inflammation caused by senescent cells: two proposed reasons why we age.

“Thus AKG may bridge cellular energy metabolism and increase amino acid availability to inhibit the secretory of inflammatory cytokines” (4)

“AKG suppresses chronic inflammation and induces secretion of IL-10 in T cells of female mice” (8)

CaAKG also contributes to metabolism, providing energy for cellular processes. It helps stimulate collagen and protein synthesis and influences age-related processes including stem cell proliferation. Increasing Calcium Alpha-Ketoglutarate in the body supports your liver and its detoxification abilities.

LIPO CaAKG™ offers advanced support for:

▸  Restoring and maintaining DNA integrity

▸  Athletic performance and recovery

▸  Managing age-related inflammation

▸  Oxidative stress

▸  Cellular Detoxification

Lipo HLA

Hyaluronic Acid is a polysaccharide molecule, one of the main components in connective tissue and which forms a gelatinous matrix that surrounds cells.

HLA Promotes New Cell Growth and Reduces Inflammation

Hyaluronic acid (HLA) is important for promoting the growth of new cells and tissues in the joint’s cartilage and bone, thereby reducing joint inflammation and pain caused by injuries or tissue degeneration.

“Our results show that HA was able to inhibit, in a dose-related fashion, both types of inflammatory reactions” (5)

“the studies reviewed here show promising results for the use of HA in the treatment of inflammatory pathologies” (6)

HLA is also a key molecule involved in skin hydration.  The natural production of Hyaluronic Acid rapidly declines by up to 50% by the time we’re 50 years old. Studies show that consuming extra hyaluronic acid boosts the body’s natural production of collagen.

LIPO HLA™ offers advanced support for:

▸  Restoring youthful skin

▸  Reducing joint pain and inflammation

▸  Healthy digestion

▸  Preserving bone mass

 

References:

1 – “Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis”

2 – “Mechanistic studies exhibit that berberine induces autophagic death in ALL cells by inactivating AKT/mTORC1 signaling”

3 – “The beneficial effects of BBR are attributable to its effect as an AMPK activator”

4 – “Thus AKG may bridge cellular energy metabolism and increase amino acid availability to inhibit the secretory of inflammatory cytokines”

5 – “Hyaluronic acid modulates acute and chronic inflammation”

6 – “Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation”

7 – “Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes”

8 – “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice”

Liposomal Solves the Bioavailability Issue

Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes Demonstration

Why Liposomes Are Needed

Bioavailability Issues

Solves the Bioavailibility Problem

The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2 Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.

Targeted Delivery

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3

Advanced Absorption

Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4

Biocompatibility

Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5

Masking

Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6

Crosses the Blood Brain Barrier

Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7

Nanoscale Power

This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8

What are Liposomes made of?

The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system. improved its oral bioavailability and increase peak plasma concentration. 9

What does phosphatidylcholine do?

Phosphatidyl­choline is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10

How do Liposomes work?

Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.

References

1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave

Key Advantages of Liposomal Delivery:

  • Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
  • Optimizes both hydrophilic and hydrophobic, unstable compounds.
  • Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
  • Provides a larger nutrient payload per particle.
  • Offers higher bioavailability and absorption compared to conventional capsules.
  • Increases increase peak plasma concentration.

Research on Liposomes for Increased Bioavailability

Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2

Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3

Water Solubility

Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.

For best results, take one (1) capsule daily as a dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

Store in a cool, dry place.

UK Delivery Information

Once ordered and payment has been received, your item(s) will be dispatched within one working day.

All packages are sent by DPD Tracked and are expected to arrive in 1-2 working days from the dispatch date.

Northern Ireland and Scottish Highlands may take 3-5 working days.

Jersey and Guernsey require a delivery charge of £3.95, but UK VAT will be removed.

Delivery times and order tracking

All courier orders via DPD will be delivered usually between 9.00 am and 6.00 pm Monday to Friday and in some areas Saturday. If you have any concerns about your delivery, please email us at info@nadlab.uk, or phone our customer services on +44 3333 012 123, and we will be happy to help.

Arranging your delivery with DPD

DPD will contact you by email to arrange your delivery. You can choose to leave your parcel in a safe place, change the delivery date, or collect it from a pickup shop.

Prostaphane Chilled Delivery

Like many other supplements and vitamins, Prostaphane may gradually lose potency when exposed to heat.

Although not essential, we send all Prostaphane shipments in chilled temperature-controlled packaging to provide an additional 48 hours of protection. However, we are assured by the manufacturer that Prostaphane is not significantly affected at higher temperatures for over a month.

Once your Prostaphane arrives, store them in your refrigerator to retain maximum potency. We keep your Prostaphane supplements in refrigerated storage at our distribution centre.

Delivery to Europe & Worldwide will be available by DHL Express only for £19.95 to ensure maximum potency.

Rest Of The World

Please see below for delivery availability and charges to Europe.

DHL Express will fulfil delivery to other countries for £29.95, taking 1-7 working days.

Please use https://renuebyscience.com/ for delivery to the US and Canada.

I am sorry, we cannot deliver to India, Russia, China, or Macau.

Customs and VAT for EU and Worldwide

To EU & Worldwide shipping addresses, VAT is not applied at the UK rate of 20% and will, instead, be due at your country’s customs office. This is to ensure you do not pay VAT twice.

*Your countries’ customs may charge import charges, VAT and processing fees. Processing fees can be between 5 and 20 euros.*

Please see here for more information – https://nadlab.uk/brexit-changes-for-eu-customers/.

EU Delivery Information

You may wish to use NAD Lab EU – https://nadlab-eu.com/ to avoid customs procedures. However, you may continue using NAD Lab UK if you wish.

*For deliveries to the Canary Islands, Iceland, Liechtenstein, Norway, and Switzerland, please continue to use NAD Lab UK.*

Standard delivery varies between 3 and 4 weeks, with DHL Express taking between 1 and 4 working days.

*ADDITIONAL CHARGES: If your delivery location is outside of the main cities and towns, DHL delivery charges may be more than expected. We may, therefore, request a contribution from you towards the additional charge. A local mail service option will be offered as an alternative, or to select a different delivery address.

Due to recent regulation changes from 1 July 2021, which have caused significant issues with customs, changes have been made to delivery options.

CountryStandard CostExpected TimeDHL Express
Austria£6.954-6 working days£19.95
Belgium£9.95 (local mail)7-14 working days£19.95
BulgariaNot availablePlease use NAD LAB EU
Croatia£9.95 (local mail)7-14 working days£19.95
CyprusDHL Express Only£19.95
Czech RepublicNot availablePlease use NAD LAB EU
DenmarkDHL Express Only£19.95
Estonia£9.95 (local mail)7-14 working days£19.95
FinlandDHL Express Only£19.95
France£6.954-6 working days£19.95
GermanyDHL Express Only£19.95
Gibraltar£9.95 (local mail)2-4 weeks£19.95
GreeceDHL Express Only£19.95
Hungary£9.95 (local mail)7-14 working days£19.95
Iceland£9.95 (local mail)10-15 working days£19.95
Ireland£6.953-5 working days£19.95
Italy£6.954-6 working days£19.95
Latvia£9.95 (local mail)7-14 working days£19.95
Liechtenstein£9.95 (local mail)10-15 working days£19.95
LithuaniaNot availablePlease use NAD LAB EU
Luxembourg£9.95 (local mail)7-14 working days£19.95
Malta£9.95 (local mail)2-4 weeks£19.95
Netherlands£6.954-6 working days£19.95
Norway£9.95 (local mail)10-15 working days£19.95
PolandNot availablePlease use NAD LAB EU
PortugalNot availablePlease use NAD LAB EU
RomaniaNot availablePlease use NAD LAB EU
SlovakiaNot availablePlease use NAD LAB EU
SloveniaNot availablePlease use NAD LAB EU
Spain Mainland£6.954-6 working daysNot available
Canary Islands£9.95 (local mail)2-4 weeks£19.95
SwedenDHL Express Only£19.95
Switzerland£9.95 (local mail)10-15 working days£19.95

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:

– Issue a full refund for unopened products
– Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please email info@nadlab.uk with your complete name, address, phone # and order #. Once we have received this email, we will provide you with a return authorisation number. Please then return the package to the below address.

Once we receive your return package, you will receive your refund. You will either be credited back to your Card or PayPal. Please allow 7 days to process the refund and 10 working days to receive your refund by card.

NOTE: The customer is responsible for all delivery charges when sending the product back to us.

Call Monday-Friday between 9 am and 5 pm with any questions.

03333 012 123

For returns, please use the following address:

NAD Lab UK
64A Dukesway, Stockton on Tees, TS17 9LT

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