NAD+ Energiser – H2S, Nitric Oxide stimulator (60 Capsules)

NAD+ Energiser – H2S, Nitric Oxide stimulator (60 Capsules)

£29.95

Out of stock

£29.95

  • Taurine
  • NAC – N-Acetyl Cysteine
  • Allicin (From Garlic extract)
  • Astaxanthin
  • Methyl Folate

900 Mg per capsule. Take 1-2 capsules per day to increase levels of nitric oxide and hydrogen sulfide in the bloodstream which research has shown can increase the effectiveness of NAD+ boosters.

 

 

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  • Description
  • What is Taurine?
  • What Is H2S?
  • What Is NAC – N-Acetyl Cysteine?
  • Delivery
  • Money Back Guarantee

Description

What is NAD+?

NAD+, or nicotinamide adenine dinucleotide, is a coenzyme found in all living cells, and it’s required for the fundamental biological processes that make life possible.

But NAD+ levels decline as we age. NAD+ has two general sets of reactions in the human body: helping turn nutrients into energy as a key player in metabolism and working as a helper molecule for proteins that regulate other biological activity.

Increased NAD+ levels stimulate energy metabolism, DNA repair, and Sirtuin activity. Sirtuins are the longevity-genes shown to be active during caloric restriction and life-extension in many animal models.

  • Boosts Energy Metabolism
  • Promotes Healthy Brain and Cardiovascular Function
  • Anti-Ageing DNA Repair
  • SIRTUIN Activator – NAD+ is required for our longevity genes to work.

Scientists have now confirmed a direct link between falling NAD+ levels and ageing in both animals and human subjects. A breakthrough study published by Harvard scientists in 2013 showed for the first time that some aspects of ageing might be reversible. The research and understanding into NAD+ metabolomics are ongoing, but what the science has highlighted thus far, is the importance of supporting and maintaining our NAD+ levels.

There are currently several human clinical trials underway that are going to help answer this very question. Dr. Sinclair has been leading the charge in this field for years. Watch the video below to hear what Dr. Sinclair has to say about where we are today.

Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health

But the truly intriguing finding was this: plasma H2S levels in the taurine group rose from 43.8 µmol/L at baseline to 87.0 µmol/L after 12 weeks (p<0.001)—a virtual doubling of plasma H2S.

 

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study

Taurine supplementation significantly improved endothelium-dependent and endothelium-independent vasodilation and increased plasma H2S and taurine concentrations… The results showed that taurine treatment upregulated the expression of hydrogen sulfide-synthesizing enzymes

Like NMN, levels of H2S (Hydrogen Sulfide) in the bloodstream decrease with age. There has been a lot of research on the therapeutic effects of increased blood plasma H2S in atherosclerosis, cardiac remodeling, and myocardial ischemia-reperfusion injury (2).

More exciting is the synergy from increased NAD+ and H2S levels together.

This  research, published March 22 in Cell, scientists at Harvard Medical School, Massachusetts Institute of Technology (MIT)  NMN  and H2S to 20-month-old mice, an age comparable to 70 years in people. After two months, the mice had increased muscular blood flow, enhanced physical performance and endurance and the old mice became as fit and strong as young mice.

precursors to NAD+ and H2S may not only be effective agents for increasing the recovery from vessel blockages and enhancing the effects of exercise, but also for treating the most common of age-related diseases, if not aging itself.

Direct supplementation with H2S is not safe for humans, but researchers are finding natural products that can increase blood plasma levels of H2S safely and effectively.  We have been testing those for the last 3 years and have combined those we found work best.

Research on the effectiveness of increasing blood levels of H2s for cardiovascular health:

Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases(Zhang, sept2018)

More and more recent studies have supported the protective effects of endogenous H2S and exogenous H2S-releasing compounds (such as NaHS, Na2S, and GYY4137) in cardiovascular diseases, such as cardiac hypertrophy, heart failure, ischemia/reperfusion injury, and atherosclerosis (Zhang, sept2018)

 

H2S Donors Prevents Atherosclerosis in vivo

NaHS administration significantly reduced the severity of atherosclerosis (Liu et al., 2013), and  reversed these changes in atherosclerotic rats (Li et al., 2015c)

 

H2S plays a significant protective role in atherosclerosis, cardiac hypertrophy, heart failure, and myocardial ischemia. Mechanisms responsible for these protective effects include down-regulation of oxidative stress responses, restoration of mitochondrial function, regulation of autophagy, attenuation of apoptosis, and increased blood vessel growth and angiogenesis

 

This  research, published March 22 in Cell, scientists at Harvard Medical School, Massachusetts Institute of Technology (MIT)  NMN  and H2S to 20-month-old mice, an age comparable to 70 years in people. After two months, the mice had increased muscular blood flow, enhanced physical performance and endurance and the old mice became as fit and strong as young mice.

precursors to NAD+ and H2S may not only be effective agents for increasing the recovery from vessel blockages and enhancing the effects of exercise, but also for treating the most common of age-related diseases, if not aging itself.

“We’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise,” said study senior investigator David Sinclair, Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.

After two months of receiving NMN, new blood vessels sprouted within the skeletal muscles of old mice. Capillary density increased and matched the capillary growth of young mice.

Remarkably, blood flow increased and the animals’ endurance (measured by how long they could run on a treadmill before before exhausting) was 56%-80% greater than that of untreated old mice: 1,400 feet compared to 780 feet.

  • NMN restored the vascular system of old mice to that of young mice
  • Mice treated with NMN had a 1.6-fold increase in time and distance runs compared to untreated mice

NMN restored the blood-vessel- and muscle-boosting effects of a good treadmill run, basically “reversing vascular aging in the mice,” said study co-leader, David Sinclair of Harvard Medical School.

N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production(Ezerina, Apr2018)

N-acetyl-L-cysteine (NAC), which acts as a precursor of H2S synthesis

Here we show that NAC-derived cysteine is desulfurated to generate hydrogen sulfide, which in turn is oxidized to sulfane sulfur species, predominantly within mitochondria and are the actual mediators of the immediate antioxidative and cytoprotective effects provided by NAC

Delivery Information

Once ordered and payment has been received, if in stock, your item(s) will be dispatched within one working day.

All packages are sent Royal Mail 48 Tracked and Signed For, expected to arrive in 2-3 days. We will provide your tracking number by email and it can be found in your account orders section by clicking here.

Pre-orders

Due to a recent surge in demand we & our supplier have been running low on stock. As items sell out, they will become available for pre-order only, whilst we await a new delivery from our supplier.

Expected dates for arrival are estimates made by our supplier and may change. As updates are received all customers will be notified by email.

We apologise for the inconvenience and we hope to avoid these circumstances in future.

EU Orders

Once ordered and payment has been received, if in stock, your item(s) will be dispatched within one working day.

Tracked & signed for delivery in 5-7 days is £6.95 to the following countries:

Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Gibraltar, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxemburg, Malta, Monaco, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden.

We no longer have restrictions on order value. However, if you wish to order more than £1,000 we will require your first order to be paid via IBAN.

Rest of the World

Please email info@nadlab.uk for a delivery quote.

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below.We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining

Return Procedures: Please send an email to info@nadlab.uk with your complete name, address, phone # and your order # . Once we have received this email, we will provide you with a return authorisation number. Please then return package to the below address.

Once we receive your return package, you will receive your refund. You will either be credited back to your Card, or PayPal. Please allow 7 days days to process the refund and up to 10 working days to receive your refund by card.

NOTE: Customer is responsible for all delivery charges incurred when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

03333 012 123

For returns please use the following address:

NAD Lab UK
64A Dukesway, Stockton on Tees, TS17 9LT

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