NMN with Resveratrol Liposomal Sublingual Gel (75 servings)
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- 75 servings per bottle
- 240 mg NMN + 40 mg Resveratrol per serving (2 pumps)
- 150 ml bottle
- Third party tested for purity (over 99%) and safety – see certificates attached
- cGMP Certified – This product was made in an FDA approved facility
- No artificial colours, flavours or preservatives. Non-GMO
- Suitable for vegans
LSG Nicotinamide Mononucleotide is a novel nanoliposomal nutrient delivery system offering enhanced bio-performance. The concentrated hydrogel absorption technology offers sustained release for prolonged bioavailability and the nanotechnology utilises pharmaceutical grade, organic, non-GMO phospholipids designed to deliver unmetabolised nutrients to cells and tissues.
MONEY BACK GUARANTEE
- What is a Liposome?
- Certificates of Analysis
- Suggested Use
- Money Back Guarantee
NMN with Resveratrol LIPO Gel is designed to deliver the most potent dose of NMN via nanoscale liposomes to increase your body’s NAD+ levels. This optimizes the mitochondrial matrix, repairs DNA and slows down the aging process.
The liposomes protect the NMN from degradation in the harsh environment of the digestive system and deliver it directly to the cells and tissues. The sustained release means very little NMN is degraded to nicotinamide.
This reduces the concern for over-methylation or inhibiting sirtuins, as what happens with taking standard (non-liposomal) capsules. We have also added liposomal resveratrol for its great benefits to the circulatory system and its antioxidative and anti-inflammatory properties.
Benefits May Include
- Restoration of intracellular NAD+ levels as they were in youth
- Activation of sirtuins, which are vital to regulating metabolic health, circadian rhythm, detoxification and cellular aging
- Increased energy
- Better sleep
Our LIPO Gels combine our superior liposomal manufacturing process with fast acting sublingual delivery. Liposomal products are far more bioavailable than traditional NMN and lasts much longer in the body. Couple that with sublingual delivery and you truly take advantage of the best of both worlds.
These Gels are a great option for people who have trouble swallowing pills but want to take advantage of our liposomal products. All it takes is two pumps under the tongue and let it absorb for 30-60 seconds before swallowing.
NAD+ products have very poor bioavailability unless a delivery method is used that can protect the ingredient from digestion. When taken in regular capsules, less than 10% of NMN or NR make it to the bloodstream intact.
To address this problem, in 2016 Alive By Science pioneered Sublingual delivery of NMN, and since then have advanced the industry further with Intranasal, Transdermal, and Liposomal NMN products.
Here we compare each of these, highlighting their unique strengths to help you decide which product is right for you.
* These assessments are relative. For example, ALL our products provide much greater bioavailability than standard capsules (which we do not offer), but we highlight liposomal delivery as it is more bioavailable than sublingual. All forms get a checkmark for “Improved energy” as they are nearly equal.
Convenience/Portability – This is ideal for those who want the ability to take NMN with them throughout the day. Our sublingual tablets, LIPO capsules, and nasal spray are ideal for those who are on the go and who like to take NMN at different intervals throughout the day.
Fast Acting – If fast acting is important to you, then we recommend our sublingual powder, tablets, or nasal spray as they bypass digestion. They can provide rapid absorption and reach systemic circulation for a noticable effect in minutes. So whether it’s before a quick workout or you need to quickly focus on mental tasks, these products can give you a quick boost when you need it most.
Long Lasting – LIPO NMN lasts longer in the body than our other NMN products. Liposomes protect the active ingredients from digestion and release slowly in the bloodstream up to 24 hours.
Fastest Cognitive Effect– The sublingual powder has a very fast effect on physical energy, but the intranasal spray has a much stronger impact on improved cognition (the relief of “brain fog”).
Improved Energy– Sublingual delivery is much faster acting and the energy boost is more quickly noticed, but the most common report from users of all NAD+ boosters is increased energy.
Easiest to Take – Some people have trouble swallowing pills or applying powder under the tongue. For those people, LSG NMN is easier because it comes in an easy to apply liquid gel.
Best Bioavailability – Approximately 30% of NMN taken sublingually gets absorbed directly into the bloodstream, while the rest passes through the GI tract and gets broken down into less effective nicotinamide. However liposomal delivery avoids degradation in the GI tract entirely, meaning far more NMN is delivered to the tissues intact.
Best Cost per Milligram – The NMN product with the best price is our sublingual powder as there is very little added cost for processing. Tablets are next. Manufacturing of Liposomes takes the most time and expensive machinery, so cost the most per Milligram.
Best Overall Value – The best overall value is the product which is best in price combined with best bioavailability. Bioavailability is how much of the product actually makes it to the cells intact. For example, our LIPO capsules cost more per milligram to manufacture, but are 3 to 5 times more bioavailable than sublingual products, so are much more cost effective.
Liposomal Solves the Bioavailability Issue
Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
Why Liposomes Are Needed
Solves the Bioavailibility Problem
The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2 Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.
Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3
Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4
Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5
Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6
Crosses the Blood Brain Barrier
Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7
This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8
What are Liposomes made of?
What does phosphatidylcholine do?
Phosphatidylcholine is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10
How do Liposomes work?
Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.
1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave
Key Advantages of Liposomal Delivery:
- Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
- Optimizes both hydrophilic and hydrophobic, unstable compounds.
- Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
- Provides a larger nutrient payload per particle.
- Offers higher bioavailability and absorption compared to conventional capsules.
- Increases increase peak plasma concentration.
Research on Liposomes for Increased Bioavailability
Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2
Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3
Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.
A Certificate of Analysis is a document issued by Quality Assurance that confirms that a regulated product meets its product specification.
For best results, place two (2) pumps under the tongue twice per day and allow to absorb. May be taken with or without food.
The pump mechanism is loaded. It may take 10-20 pumps to prime before first use. Target the tip of the pump under the tongue. Press down to administer LSG™. Put the cap back on the pump when done.
If swallowed, liposomes do protect the active ingredients from digestion in the stomach, but it is preferable to let the gel absorb under the tongue or elsewhere in the oral cavity as much as possible.
LSG™ NMN is nanoliposome-encapsulated Nicotinamide Mononucleotide, offering advanced absorption in sustained release sublingual hydrogel technology.
Our liposomes encapsulate NMN into nanometer sized vesicles – between 20-40 nm – to protect it from denaturation.
Our LSG delivery system protects the full functionality of NMN.
NMN engulfed in liposomes protects it from degradation, providing its unmetabolized form directly to cells and tissues.
Store in a cool, dry, dark place.
UK Delivery Information
Once ordered and payment has been received, your item(s) will be dispatched within one working day.
All packages are sent by DPD Tracked and are expected to arrive in 1-2 working days from the dispatch date.
Northern Ireland and Scottish Highlands may take 3-5 working days.
Jersey and Guernsey require a delivery charge of £3.95, but UK VAT will be removed.
Delivery times and order tracking
All courier orders via DPD will be delivered usually between 9.00 am and 6.00 pm Monday to Friday and in some areas Saturday. If you have any concerns about your delivery, please email us at email@example.com, or phone our customer services on +44 3333 012 123, and we will be happy to help.
Arranging your delivery with DPD
DPD will contact you by email to arrange your delivery. You can choose to leave your parcel in a safe place, change the delivery date, or collect it from a pickup shop.
Prostaphane Chilled Delivery
Like many other supplements and vitamins, Prostaphane may gradually lose potency when exposed to heat.
Although not essential, we send all Prostaphane shipments in chilled temperature-controlled packaging to provide an additional 48 hours of protection. However, we are assured by the manufacturer that Prostaphane is not significantly affected at higher temperatures for over a month.
Once your Prostaphane arrives, store them in your refrigerator to retain maximum potency. We keep your Prostaphane supplements in refrigerated storage at our distribution centre.
Delivery to Europe & Worldwide will be available by DHL Express only for £19.95 to ensure maximum potency.
Rest Of The World
Please see below for delivery availability and charges to Europe.
DHL Express will fulfil delivery to other countries for £29.95, taking 1-7 working days.
Please use https://renuebyscience.com/ for delivery to the US and Canada.
I am sorry, we cannot deliver to India, Russia, China, or Macau.
Customs and VAT for EU and Worldwide
To EU & Worldwide shipping addresses, VAT is not applied at the UK rate of 20% and will, instead, be due at your country’s customs office. This is to ensure you do not pay VAT twice.
*Your countries’ customs may charge import charges, VAT and processing fees. Processing fees can be between 5 and 20 euros.*
Please see here for more information – https://nadlab.uk/brexit-changes-for-eu-customers/.
EU Delivery Information
You may wish to use NAD Lab EU – https://nadlab-eu.com/ to avoid customs procedures. However, you may continue using NAD Lab UK if you wish.
*For deliveries to the Canary Islands, Iceland, Liechtenstein, Norway, and Switzerland, please continue to use NAD Lab UK.*
Standard delivery varies between 3 and 4 weeks, with DHL Express taking between 1 and 4 working days.
*ADDITIONAL CHARGES: If your delivery location is outside of the main cities and towns, DHL delivery charges may be more than expected. We may, therefore, request a contribution from you towards the additional charge. A local mail service option will be offered as an alternative, or to select a different delivery address.
Due to recent regulation changes from 1 July 2021, which have caused significant issues with customs, changes have been made to delivery options.
|Country||Standard Cost||Expected Time||DHL Express|
|Austria||£6.95||4-6 working days||£19.95|
|Belgium||£9.95 (local mail)||7-14 working days||£19.95|
|Bulgaria||Not available||Please use NAD LAB EU|
|Croatia||£9.95 (local mail)||7-14 working days||£19.95|
|Cyprus||DHL Express Only||£19.95|
|Czech Republic||Not available||Please use NAD LAB EU|
|Denmark||DHL Express Only||£19.95|
|Estonia||£9.95 (local mail)||7-14 working days||£19.95|
|Finland||DHL Express Only||£19.95|
|France||£6.95||4-6 working days||£19.95|
|Germany||DHL Express Only||£19.95|
|Gibraltar||£9.95 (local mail)||2-4 weeks||£19.95|
|Greece||DHL Express Only||£19.95|
|Hungary||£9.95 (local mail)||7-14 working days||£19.95|
|Iceland||£9.95 (local mail)||10-15 working days||£19.95|
|Ireland||£6.95||3-5 working days||£19.95|
|Italy||£6.95||4-6 working days||£19.95|
|Latvia||£9.95 (local mail)||7-14 working days||£19.95|
|Liechtenstein||£9.95 (local mail)||10-15 working days||£19.95|
|Lithuania||Not available||Please use NAD LAB EU|
|Luxembourg||£9.95 (local mail)||7-14 working days||£19.95|
|Malta||£9.95 (local mail)||2-4 weeks||£19.95|
|Netherlands||£6.95||4-6 working days||£19.95|
|Norway||£9.95 (local mail)||10-15 working days||£19.95|
|Poland||Not available||Please use NAD LAB EU|
|Portugal||Not available||Please use NAD LAB EU|
|Romania||Not available||Please use NAD LAB EU|
|Slovakia||Not available||Please use NAD LAB EU|
|Slovenia||Not available||Please use NAD LAB EU|
|Spain Mainland||£6.95||4-6 working days||Not available|
|Canary Islands||£9.95 (local mail)||2-4 weeks||£19.95|
|Sweden||DHL Express Only||£19.95|
|Switzerland||£9.95 (local mail)||10-15 working days||£19.95|
Guarantee and Return Policy
We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:
– Issue a full refund for unopened products
– Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)
Return Procedures: Please email firstname.lastname@example.org with your complete name, address, phone # and order #. Once we have received this email, we will provide you with a return authorisation number. Please then return the package to the below address.
Once we receive your return package, you will receive your refund. You will either be credited back to your Card or PayPal. Please allow 7 days to process the refund and 10 working days to receive your refund by card.
NOTE: The customer is responsible for all delivery charges when sending the product back to us.
Call Monday-Friday between 9 am and 5 pm with any questions.
03333 012 123
For returns, please use the following address:
NAD Lab UK
64A Dukesway, Stockton on Tees, TS17 9LT