SLC NMN Capsules (60 x 250mg)

£54.95

  • Impervious to low pH (acidic) enviroment
  • Dissolves in high pH of small intestine
  • Protects NMN from digestion by bacteria in stomach
  • Includes Sodium Bicarbonate to maximise absorption, TMG as a methyl replacement and Zinc to increase immunity
  • Total 15 g of NMN per bottle
  • Over 99% Purity (see images)

 

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Description

Why SLC NMN?

Research has increasingly shown that NAD+ and it’s precursors are almost entirely digested in the Gastro-Intestinal tract.  So in 2017 we quit selling capsules to focus on powders and tablets designed for sublingual use, even though we were the biggest seller of NMN capsules on Amazon and through our website.

Then, 2 research studies were published in 2019 and 2020. The first showed the SLC12a8 enzyme prevalent in the small intestine can transport some NMN directly into cells as NAD+. The second shows that bacteria in the stomach actually consume nearly all NMN before it reaches the small intestine.

So we designed our SLC NMN with an Acid Resistant capsule that dissolves only when reaching the high PH (base) environment of the small intestine.  The NMN can then utilise the SLC12a8 transporter in far greater quantity, along with other ingredients added to maximise uptake by the SLC12a8 enzyme.

Bioavailability Problem with Standard Capsules

The 2018 Liu/Rabinowitz study found that very little, if any, NMN or NR make it past the liver into the bloodstream.

Even more striking, this 2020 study found most NMN never makes it to the liver, but is almost completely digested by bacteria in the stomach.

The yellow and red bars show NMN and NAD+ in the gastrointestinal tract are many times higher in mice given antibiotics (ABX) or NMN + Antibiotics (NMN + ABX).

This explains why regular NMN capsules perform so poorly compared to sublingual delivery of NMN, that can bypass the stomach and liver to deliver NMN directly to the bloodstream.

The NMN Transporter – SLC12a8

This 2019 study found some NMN (but not NR) can be transported directly through the cell membrane and converted to NAD+ by the newly discovered SLC12a8 enzyme inside the small intestine.

Does the SLC12a8 Transporter mean all NMN capsules are as effective as Sublingual?

No. The quantity that is absorbed utilizing the Slc12a8 enzyme is not thought to be the the majority.

According to the authors:

“It is important to note that the discovery of an NMN transporter by no means diminishes the importance of uptake via dephosphorylation.”

There is hope the Slc12a8 Transporter can be useful.

“Dr. Imai’s lab already has identified small molecules that can stimulate production of the Slc12a8 NMN transporter, applied for patents, and licensed this technology to a company in Japan.”

Doubts about SLC12a8

There are a some die-hard Nicotinamide Riboside (NR) belivers such as Chromadex chief science advisor, Dr. Brenner, who refuse to accept the reseach on Slc12a8 NMN Transporter, but most accept the science.

However, there is huge variation between individuals and testing to quantify how much NMN is actually transported by SLC12a8 has not yet been published.  There is much indirect evidence and researchers generally believe it is less than 10% with standard delivery methods.

A Certificate of Analysis is a document issued by Quality Assurance that confirms that a regulated product meets its product specification.

Here we have results obtained from testing made by Delano Labs, Micro Quality Labs, and Summit Nutritional Laboratories performed as part of quality control of an individual batch of a product.

Research released in 2018 suggested taking NAD+ & NMN supplements sublingually (under the tongue) may be more effective than taking oral capsules, as it is rapidly absorbed directly to the bloodstream, bypassing the digestive system where the most waste occurs.

This 2018 research showed that oral supplements of NR and NMN are digested to Nicotinamide (NAM) in the liver, with very little reaching the bloodstream. The absorption of the different molecules delivered through the sublingual route can be 3 to 10 times greater than oral route and is only surpassed by nasal and direct IV injection.

We have partnered with the leading pharmaceutical sublingual products manufacturer to supply you with the first NMN and NAD+ sublingual powder, tablets, liquid drops and nasal spray that have the ideal characteristics to ensure efficient and rapid uptake.

For best results, take two (2) capsules daily as a dietary supplement.

However, benefits have been recorded as low as 250mg, 1 capsule (250mg) will have an effect on your bodies NAD+ levels. Please adjust your dosage according to your budget and lifestyle.

May be taken with or without meals.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

Store in a cool, dry place.

UK Orders

Once ordered and payment has been received, if in stock, your item(s) will be dispatched within one working day.

All packages are sent by DPD Tracked and are expected to arrive in 1-2 working days from dispatch date. Northern Ireland and Scottish Highlands may take longer. We will provide your tracking number by email and it can be found in your account orders section by clicking here.

Jersey and Guernsey requires a delivery charge of £3.95, but UK VAT will be removed.

Pre-orders

Due to a recent surge in demand we & our supplier have been running low on stock. As items sell out, they may become available for pre-order only, whilst we await a new delivery from our supplier.

Expected dates for arrival are estimates made by our supplier and may change. As updates are received all customers will be notified by email.

If a pre order product is ordered in the same order as an in stock product, we may await for all products to be in stock before your items are dispatched.

We apologise for the inconvenience and we hope to avoid these circumstances in future.

EU Orders - Awaiting opening on EU distribution location end of 2021.

Once ordered and payment has been received, if in stock, your item(s) will be dispatched within one working day.

We no longer have restrictions on order value. However, if you wish to order more than £750 we will require your first order to be paid via IBAN.

Due to recent regulation changes from 1 July 2021 which has caused significant issues and delays using our road delivery services, changes have been made to delivery options. I am very sorry but we are no longer able to deliver to Iceland, Romania or Lithuania.

DPD tracked delivery £7.95 and DHL Express (1-4 working days) £19.95

Austria, France, Germany, Republic of Ireland, Netherlands, Spain - Mainland.

Local mail service (7-14 days) £9.95 and DHL Express (1-4 working days) £19.95

Belguim, Sweden, Croatia, Czech Republic, Estonia as well as non EU countries; Liechtenstein, Norway, and Switzerland

ONLY Local mail service (7-14 days) £9.95

Gibraltar , Malta, Spain - Canary Islands,

ONLY DHL Express (1-4 days) £19.95

Cyprus, Finland, Portugal, Poland, Denmark, Greece

We are very sorry, we no longer delivery to:

Iceland, Romania or Lithuania

Rest of the World

Delivery to other countries will be fulfilled by DHL Express for £29.95.

Customs and VAT for EU (following Brexit) and Worldwide

To EU & Worldwide shipping addresses, VAT is not applied at the UK rate of 20% and VAT will, instead, be due at your countries customs office. This is to ensure you do not pay VAT twice. You may also be liable for import duty upon arrival.

Please see here for more information - https://nadlab.uk/brexit-changes-for-eu-customers/.

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below.We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please send an email to info@nadlab.uk with your complete name, address, phone # and your order # . Once we have received this email, we will provide you with a return authorisation number. Please then return package to the below address.

Once we receive your return package, you will receive your refund. You will either be credited back to your Card, or PayPal. Please allow 7 days days to process the refund and up to 10 working days to receive your refund by card.

NOTE: Customer is responsible for all delivery charges incurred when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

03333 012 123

For returns please use the following address:

NAD Lab UK
64A Dukesway, Stockton on Tees, TS17 9LT

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