SLC NMN Capsules (60 x 250mg)

£54.95

  • Impervious to low pH (acidic) enviroment
  • Dissolves in high pH of small intestine
  • Protects NMN from digestion by bacteria in stomach
  • Includes Sodium Bicarbonate to maximise absorption, TMG as a methyl replacement and Zinc to increase immunity
  • Total 15 g of NMN per bottle
  • Over 99% Purity (see images)

 

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Description

Why SLC NMN?

Research has increasingly shown that NAD+ and it’s precursors are almost entirely digested in the Gastro-Intestinal tract.  So in 2017 we quit selling capsules to focus on powders and tablets designed for sublingual use, even though we were the biggest seller of NMN capsules on Amazon and through our website.

Then, 2 research studies were published in 2019 and 2020. The first showed the SLC12a8 enzyme prevalent in the small intestine can transport some NMN directly into cells as NAD+. The second shows that bacteria in the stomach actually consume nearly all NMN before it reaches the small intestine.

So we designed our SLC NMN with an Acid Resistant capsule that dissolves only when reaching the high PH (base) environment of the small intestine.  The NMN can then utilise the SLC12a8 transporter in far greater quantity, along with other ingredients added to maximise uptake by the SLC12a8 enzyme.

Bioavailability Problem with Standard Capsules

The 2018 Liu/Rabinowitz study found that very little, if any, NMN or NR make it past the liver into the bloodstream.

Even more striking, this 2020 study found most NMN never makes it to the liver, but is almost completely digested by bacteria in the stomach.

The yellow and red bars show NMN and NAD+ in the gastrointestinal tract are many times higher in mice given antibiotics (ABX) or NMN + Antibiotics (NMN + ABX).

This explains why regular NMN capsules perform so poorly compared to sublingual delivery of NMN, that can bypass the stomach and liver to deliver NMN directly to the bloodstream.

The NMN Transporter – SLC12a8

This 2019 study found some NMN (but not NR) can be transported directly through the cell membrane and converted to NAD+ by the newly discovered SLC12a8 enzyme inside the small intestine.

Does the SLC12a8 Transporter mean all NMN capsules are as effective as Sublingual?

No. The quantity that is absorbed utilizing the Slc12a8 enzyme is not thought to be the the majority.

According to the authors:

“It is important to note that the discovery of an NMN transporter by no means diminishes the importance of uptake via dephosphorylation.”

There is hope the Slc12a8 Transporter can be useful.

“Dr. Imai’s lab already has identified small molecules that can stimulate production of the Slc12a8 NMN transporter, applied for patents, and licensed this technology to a company in Japan.”

Doubts about SLC12a8

There are a some die-hard Nicotinamide Riboside (NR) belivers such as Chromadex chief science advisor, Dr. Brenner, who refuse to accept the reseach on Slc12a8 NMN Transporter, but most accept the science.

However, there is huge variation between individuals and testing to quantify how much NMN is actually transported by SLC12a8 has not yet been published.  There is much indirect evidence and researchers generally believe it is less than 10% with standard delivery methods.

A Certificate of Analysis is a document issued by Quality Assurance that confirms that a regulated product meets its product specification.

Here we have results obtained from testing made by Delano Labs, Micro Quality Labs, and Summit Nutritional Laboratories performed as part of quality control of an individual batch of a product.

Research released in 2018 suggested taking NAD+ & NMN supplements sublingually (under the tongue) may be more effective than taking oral capsules, as it is rapidly absorbed directly to the bloodstream, bypassing the digestive system where the most waste occurs.

This 2018 research showed that oral supplements of NR and NMN are digested to Nicotinamide (NAM) in the liver, with very little reaching the bloodstream. The absorption of the different molecules delivered through the sublingual route can be 3 to 10 times greater than oral route and is only surpassed by nasal and direct IV injection.

We have partnered with the leading pharmaceutical sublingual products manufacturer to supply you with the first NMN and NAD+ sublingual powder, tablets, liquid drops and nasal spray that have the ideal characteristics to ensure efficient and rapid uptake.

For best results, take two (2) capsules daily as a dietary supplement.

However, benefits have been recorded as low as 250mg, 1 capsule (250mg) will have an effect on your bodies NAD+ levels. Please adjust your dosage according to your budget and lifestyle.

May be taken with or without meals.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

Store in a cool, dry place.

UK Delivery Information

Once ordered and payment has been received, if in stock, your item(s) will be dispatched within one working day.

All packages are sent by DPD Tracked and are expected to arrive in 1-2 working days from dispatch date.

Northern Ireland and Scottish Highlands may 3-5 workings days.

Jersey and Guernsey requires a delivery charge of £3.95, but UK VAT will be removed.

Delivery times and order tracking

All courier orders via DPD will be delivered usually between 9.00am and 6.00pm Monday to Friday, and in some areas Saturday. If you have any concerns about your delivery then please email us at info@nadlab.uk, or phone our customer services on +44 3333 012 123 and we will be happy to help.

Arranging your delivery with DPD

DPD will contact you by email to arrange your delivery. You can choose to leave your parcel in a safe place, change delivery date, or collect from a pickup shop.

Missed deliveries

Should there be no one at home when we deliver – it’s not a problem. A calling card with instructions included so that you can re-arrange delivery for a more convenient time.

Prostaphane Chilled Delivery

Orders will only be dispatched on Monday, Tuesday and Wednesday to the UK and Europe. Any orders made after Wednesday 12pm will be sent on Monday.

Worldwide deliveries will only be sent on Monday and Tuesday to avoid any delays over the weekend.

Your Prostaphane supplements are kept in refrigerated storage at our distribution center, and are sent to you only by next day delivery. Although not essential, for further assurance, we send all Prostaphane shipments in chilled temperature controlled packaging to provide an additional 48 hours protection.

As soon as your arrive, please store them in your refrigerator.

Delivery to Europe & Worldwide will be available by DHL Express only for £19.95 to ensure maximum potency.

Rest Of The World

Please see below for delivery availability and charges to the Europe.

Delivery to other countries will be fulfilled by DHL Express for £29.95 taking 1-7 working days.

Please use https://alivebyscience.com/ for delivery to the US and Canada.

I am sorry, we are unable deliver to Russia.

Customs and VAT for EU and Worldwide

To EU & Worldwide shipping addresses, VAT is not applied at the UK rate of 20% and VAT will, instead, be due at your countries customs office. This is to ensure you do not pay VAT twice. You may also be liable for import duty for non EU countries.

Please see here for more information – https://nadlab.uk/brexit-changes-for-eu-customers/.

EU Delivery Information

You may continue to use NAD Lab UK if you wish, however NAD Lab EU – https://nadlab-eu.com/ is now open.

*For deliveries to Iceland, Liechtenstein, Norway, and Switzerland please continue to use NAD Lab UK.*

Standard delivery varies between 3 working days and 4 weeks, with DHL Express taking between 1-4 working days.

Due to recent regulation changes from 1 July 2021 which has caused significant issues with customs, changes have been made to delivery options.

CountryStandard CostExpected TimeDHL Express
Austria£6.954-6 working days£19.95
Belgium£9.95 (local mail)7-14 working days£19.95
BulgariaNot availablePlease use NAD LAB EU
Croatia£9.95 (local mail)7-14 working days£19.95
CyprusDHL Express Only£19.95
Czech Republic£9.95 (local mail)7-14 working days£19.95
DenmarkDHL Express Only£19.95
Estonia£9.95 (local mail)7-14 working days£19.95
FinlandDHL Express Only£19.95
France£6.954-6 working days£19.95
GermanyDHL Express Only£19.95
Gibraltar£9.95 (local mail)2-4 weeks£19.95
GreeceDHL Express Only£19.95
Hungary£9.95 (local mail)7-14 working days£19.95
Iceland£9.95 (local mail)10-15 working days£19.95
Ireland£6.953-5 working days£19.95
Italy£6.954-6 working days£19.95
Latvia£9.95 (local mail)7-14 working days£19.95
Liechtenstein£9.95 (local mail)10-15 working days£19.95
LithuaniaNot availablePlease use NAD LAB EU
Luxembourg£9.95 (local mail)7-14 working days£19.95
Malta£9.95 (local mail)2-4 weeks£19.95
Netherlands£6.954-6 working days£19.95
Norway£9.95 (local mail)10-15 working days£19.95
PolandNot availablePlease use NAD LAB EU
PortugalDHL Express Only£19.95
RomaniaNot availablePlease use NAD LAB EU
SlovakiaNot availablePlease use NAD LAB EU
SloveniaNot availablePlease use NAD LAB EU
Spain Mainland£6.954-6 working days£19.95
Canary Islands£9.95 (local mail)2-4 weeks£19.95
SwedenDHL Express Only£19.95
Switzerland£9.95 (local mail)10-15 working days£19.95

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below.We guarantee your satisfaction and will:

– Issue a full refund for unopened products
– Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please send an email to info@nadlab.uk with your complete name, address, phone # and your order # . Once we have received this email, we will provide you with a return authorisation number. Please then return package to the below address.

Once we receive your return package, you will receive your refund. You will either be credited back to your Card, or PayPal. Please allow 7 days to process the refund and up to 10 working days to receive your refund by card.

NOTE: Customer is responsible for all delivery charges incurred when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

03333 012 123

For returns please use the following address:

NAD Lab UK
64A Dukesway, Stockton on Tees, TS17 9LT

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